Rituximab in clinical practice: dosage, drug adherence, Ig levels, infections, and drug antibodies
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چکیده
منابع مشابه
Adherence with antihypertensive drug therapy and the risk of heart failure in clinical practice.
Randomized clinical trials have shown that antihypertensive treatment reduces the risk of heart failure (HF). Limited evidence exists, however, on whether and to what extent this benefit is translated into real-life practice. A nested case-control study was carried out by including the cohort of 76 017 patients from Lombardy (Italy), aged 40 to 80 years, who were newly treated with antihyperten...
متن کاملComputerized advice on drug dosage to improve prescribing practice.
BACKGROUND Maintaining therapeutic concentrations of drugs with a narrow therapeutic window is a complex task. Several computer systems have been designed to help doctors determine optimum drug dosage. Significant improvements in health care could be achieved if computer advice improved health outcomes and could be implemented in routine practice in a cost-effective fashion. This is an updated v...
متن کاملPharmacogenetics, drug-metabolizing enzymes, and clinical practice.
The application of pharmacogenetics holds great promise for individualized therapy. However, it has little clinical reality at present, despite many claims. The main problem is that the evidence base supporting genetic testing before therapy is weak. The pharmacology of the drugs subject to inherited variability in metabolism is often complex. Few have simple or single pathways of elimination. ...
متن کاملDrug Dosage Formulations
The discovery and development of a new drug can be a lengthy and expensive business (Fig. 1). The starting point is the active compound as synthesized by the medicinal chemist and screened by the pharmacologist. There then follows a series of complex tests and evaluations to produce a satisfactory formulation and sufficient data for presentation to regulatory authorities such as the Committee o...
متن کاملDrug adherence to olmesartan/amlodipine fixed combination in an Italian clinical practice setting
OBJECTIVE To investigate the criteria for prescribing a combination pill for hypertensive patients, and whether the combination pill improves medication adherence. MATERIALS AND METHODS This was a retrospective cohort study, performed in three Italian local health units. We selected all adult subjects who received at least one prescription of antihypertensive drugs between September 1, 2011 a...
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ژورنال
عنوان ژورنال: Clinical Rheumatology
سال: 2017
ISSN: 0770-3198,1434-9949
DOI: 10.1007/s10067-017-3848-6